1) LABYRINTHINE DEVELOPMENT - - - - - Moderator - Robert Baker
8:15 - R. Baker - Development of the labyrinth
8:35 - T. Van De Water - Genetic determinants of labyrinthine structure
8:55 - I. Sando - Developmental anomalies in labyrinthine structure
9:15 - S. Rauch - Human Pathological correlation revealed by temporal bone
9:35 - Panel discussion: labyrinthine development and clinical relevance
9:55 AM COFFEE BREAK

2) LABYRINTHINE PHARMACOLOGICAL MANIPULATION - Moderator — Joel Goebel
10:10 - M. Warchol — Ototoxicity and immune regulation of hair cell regeneration
10:30 - D. Dickman- Recovery of vestibular hair cells and afferents following ototoxicity
10:50 - M. Seidman - Pharmacological manipulation of the labyrinth
11:05 - M. Hoffer - Infusion of aminoglycosides via the round window
11:20 - Panel discussion: basic and clinical ototoxicity results
11:40 AM LUNCH

3) LABYRINTHINE REGENERATION - - - - - Moderator — David Dickman -
1:00 - J. Corwin - Regeneration of hair cells
1:20 - R. Baird - Hair cell recovery in mitotically blocked saccular cultures
1:40 - M. Correia - Reappearance of hair cell ionic currents following ototoxicity
2:00 - V. Honrubia - Neurotrophic factors related to regenerating hair cells
2:20 - Panel discussion: the potential for human hair cell regeneration
2:50 PM COFFEE BREAK

4) VESTIBULAR COMPENSATION - - - - - Moderator - Gary Paige
3:00 - C. Balaban - Genetic regulation of vestibular compensation
3:20 - G. Holstein - Nitric oxide and related markers in the vestibular nuclei
3:40 - M. Strupp - Exercise, drug therapy alter recovery from labyrinth lesion in humans
4:00 - D. Zee - Applications of cerebellar physiology to evaluate vestibular compensation
4:20 - Panel discussion: factors in vestibular compensation
VIEW POSTERS from 4:40 PM
BANQUET from 6:30 PM
 
 
Friday, November 17, 2000
8:00 AM SESSIONS BEGIN

5) CANAL VERSUS OTOLITHIC FUNCTION - - - - Moderator — Dora Angelaki
8:00 - D. Angelaki - How the brain distinguishes canal from otolith input
8:20 - T. Raphan - Coordinate reference during walking, turning, and jumping
8:40 - S. Moore - LVOR and AVOR during locomotion in humans
9:00 - J. Demer - Ocular compensation due to labyrinthine input during natural motion
9:20 - Panel discussion: canal and otolithic function
9:50 AM COFFEE BREAK

6) OTOLITH ORGANS AND BPPV - - - - - Moderator — Stephen M. Highstein
10:00 - R. Thalmann - Biochemistry of the developing otolith
10:20 - J. Epley - Human experience with canal repositing maneuvers
10:40 - M. Halmagyi - Human experiences with otolithic dysfunction
11:00 - Panel discussion: Benign Paroxsismal Positional Vertigo (BPPV)

7) DEGENERATION AND AGING - - - - - Moderator - Stephen Rauch
11:20 - P. L. M. Huygen - Hereditary familial degenerative diseases
11:40 - R. Baloh - Age related changes in vestibular function
12:00 - S. Rauch - Decreasing hair cell counts in aging humans
12:20 - Panel discussion: changes in vestibular function as the population ages
12:50 PM LUNCH
1:30-2:30 PLENARY LECTURE
Dr. Bernard Cohen- Historical development of the functional role of the labyrinth in spatial perception and motor behavior.

8) SEMICIRCULAR CANAL PLUGGING - - - - Moderator - Lloyd Minor
1:40 - R. Rabbitt - Physiological effects of canal plug
2:00 - S. Yakushin - Oculomotor function following canal plug in monkeys
2:20 - L. Parnes - Human experience with canal plugging
2:40 - Panel discussion: lessons from basic science applied to canal plug in humans
3:00 PM COFFEE BREAK
ENDOLYMPHATIC HYDROPS - - - - Moderator —Isolde Thalmann -
3:15 - A. Salt - Regulation of endolymphatic fluid volume
3:35 - R. Rabbitt - Increased intralabyrinthine pressure stimulates labyrinthine responses
3:55 - G. Neely - Clinical experience with a surgical approach to hydrops
4:05 - Panel discussion: understanding labyrinthine hydrops
4:25 PM POSTER SESSION
DINNER on your own at local restaurants

Saturday, November 18, 2000
9:00 AM SESSIONS BEGIN

10) SIGNAL TRANSDUCTION BY THE SEMICIRCULAR - - Moderator — R. A. Eatock
CANALS: PROCESSING OF CANAL AND OTOLITHIC INFORMATION BY THE VESTIBULAR NUCLEI
9:00 - A. Lisakowski - Synaptic organization of the crista
9:20 - R. A. Eatock - Role of hair cell ionic currents in labyrinthine signal processing
9:40 - R. A. McCrea - Current concepts of vestibular nucleus function
10:00 - C. A. Cullen - Programming of head movement
10:20 - Panel discussion:
10:40 AM COFFEE BREAK

11) CLINICAL ISSUES IN POSTURE CONTROL - - - Moderator — Susan Herdman
11:00 - R. Boyle - Function of vestibulo-spinal neurons in head fixed and head free animals
11:20 - B. Peterson - Vestibular control of posture
11:40 - S. Herdman- Strategies for balance rehabilitation
12:00 - J. Allum — Postural control following peripheral vestibular loss
12:20 - Panel discussion concerning clinical issues in posture control
12:40 PM LUNCH

12) HOW CAN BASIC SCIENCE INFORMATION - - - Moderator — Gay Holstein
BE UTILIZED IN THE CLINICAL TESTING OF BALANCE AND EQUILIBRIUM
1:30 - M. Halmagyi - Head thrust and individual semicircular canal function
1:50 - J. Demer - New tests of vestibular function
2:10 - O. Black - What can posturagraphy tell us about vestibular function?
2:30 - Panel discussion: basic science applications in clinical testing
2:50 PM CLOSING REMARKS